Disseminated B-cell lymphoma in animal model is controlled by [superscript]213Bi-antiCD74.

2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Disseminated B-cell lymphoma in animal model is reduced, cured by [superscript]213Bi-antiCD74 monoclonal antibody therapy.

According to published research from the United States, "a [superscript]213Bi-labeled antibody (Ab) to CD74 was evaluated as a therapeutic agent for B-cell lymphoma. The alpha-particle emission, with a half-life of 46 min, is appropriate for therapy of micrometastases.

"The labeled Ab retained full immunoreactivity, and was potent at single-cell kill of the Raji B-lymphoma cell line. Approximately 30 decays of cell-bound [superscript]213Bi was required for a cell kill of 99%, and dosimetry …